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KMID : 0352720180420020225
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Journal of Ginseng Research
2018 Volume.42 No. 2 p.225 ~ p.228
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Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
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Choi Seo-Yun
Kim Kui-Jin
Song Ji-Hyeon
Lee Boo-Yong
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Abstract
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Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.
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KEYWORD
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cognitive impairment, Ginsenoside Rg5, HT22, neuroprotection, thermal stress
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